蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书NOLC1 Rabbit pAb
Cat#:DPA03031应用：WB,IHC,ICC/IF,FC
| Product Name: | NOLC1 Rabbit pAb |
| Cat No.: | DPA03031 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:100 FC: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human NOLC1 |
| Calculated Molecular Weight: | 74 kDa |
| Observed Molecular Weight: | 110 kDa |
| GenBank Accession Number: | Q14978 |
| Gene ID (NCBI): | 9221 |
| Synonyms: | P130; NOPP130; NOPP140; NS5ATP13 |
| Background: | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). |
| Category: | Primary Ab |
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