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Ionotropic Glutamate receptor 2 Rabbit pAb

Cat No.: DPA03041
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Product Name: Ionotropic Glutamate receptor 2 Rabbit pAb
Cat No.: DPA03041
Clonality: Polyclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,FC,IP
Recommended Dilution: WB: 1:1000
FC: 1:20
IP: 1:20
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human Ionotropic Glutamate receptor 2
Calculated Molecular Weight: 99 kDa
Observed Molecular Weight: 99 kDa
GenBank Accession Number: P42262
Gene ID (NCBI): 2891
Synonyms: GLUR2; GLURB; GluA2; HBGR2; GluR-K2
Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Category: Primary Ab
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