蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书KRIT1 Rabbit pAb
Cat#:DPA03237应用：WB,IHC,ICC/IF
| Product Name: | KRIT1 Rabbit pAb |
| Cat No.: | DPA03237 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human KRIT1 |
| Calculated Molecular Weight: | 84 kDa |
| Observed Molecular Weight: | 84 kDa |
| GenBank Accession Number: | O00522 |
| Gene ID (NCBI): | 889 |
| Synonyms: | CAM; CCM1 |
| Background: | This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] |
| Category: | Primary Ab |
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