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规格：
查看说明书LDL Receptor Rabbit pAb
Cat#:DPA03835应用：WB,IHC,ICC/IF,FC
| Product Name: | LDL Receptor Rabbit pAb |
| Cat No.: | DPA03835 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:100 ICC/IF: 1:20-1:100 FC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human LDL Receptor |
| Calculated Molecular Weight: | 95 kDa |
| Observed Molecular Weight: | 150 kDa |
| GenBank Accession Number: | P01130 |
| Gene ID (NCBI): | 3949 |
| Synonyms: | FH; FHC; LDLCQ2 |
| Background: | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
| Category: | Primary Ab |
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