蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书BRCA1 Rabbit pAb
Cat#:DPA04188应用：IHC,ICC/IF
| Product Name: | BRCA1 Rabbit pAb |
| Cat No.: | DPA04188 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | IHC,ICC/IF |
| Recommended Dilution: | IHC: 1:50 ICC/IF: 1:200 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human BRCA1 |
| Calculated Molecular Weight: | 208 kDa |
| GenBank Accession Number: | P38398 |
| Gene ID (NCBI): | 672 |
| Synonyms: | IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53 |
| Background: | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] |
| Category: | Primary Ab |
相关产品
