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Hsp70 Rabbit pAb

Cat No.: DPA04381
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Product Name: Hsp70 Rabbit pAb
Cat No.: DPA04381
Clonality: Polyclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,IHC,ICC/IF,IP
Recommended Dilution: WB: 1:1000
IHC: 1:200
ICC/IF: 1:20
IP: 1:50
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: Recombinant protein of mouse Hsp70
Calculated Molecular Weight: 70 kDa
Observed Molecular Weight: 70 kDa
GenBank Accession Number: P17879
Gene ID (NCBI): 15511
Synonyms: Hsp70; hsp68; Hsp70-1; Hsp70.1
Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state.
Category: Primary Ab
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