蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书EWSR1 Rabbit pAb
Cat#:DPA04388应用：WB,IHC,ICC/IF
| Product Name: | EWSR1 Rabbit pAb |
| Cat No.: | DPA04455 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human EWSR1 |
| Calculated Molecular Weight: | 69 kDa |
| Observed Molecular Weight: | 85 kDa |
| GenBank Accession Number: | Q01844 |
| Gene ID (NCBI): | 2130 |
| Synonyms: | EWS; EWS-FLI1; bK984G1.4 |
| Background: | This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009] |
| Category: | Primary Ab |
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