蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书P Glycoprotein Rabbit pAb
Cat#:DPA04470应用：WB,IHC
| Product Name: | P Glycoprotein Rabbit pAb |
| Cat No.: | DPA04470 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human P Glycoprotein |
| Calculated Molecular Weight: | 142 kDa |
| Observed Molecular Weight: | 130-180 kDa |
| GenBank Accession Number: | P08183 |
| Gene ID (NCBI): | 5243 |
| Synonyms: | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170 |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
| Category: | Primary Ab |
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