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分子生物学
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查看说明书Caspase-11 Rabbit pAb
Cat#:DPA04491应用：WB,IP
| Product Name: | Caspase-11 Rabbit pAb |
| Cat No.: | DPA04491 |
| Clonality: | Polyclonal |
| Species Reactivity: | Mouse |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of mouse Caspase-11 |
| Calculated Molecular Weight: | 43 kDa |
| Observed Molecular Weight: | 43,38,25 kDa |
| GenBank Accession Number: | P70343 |
| Gene ID (NCBI): | 12363 |
| Synonyms: | Caspl; ich-3; CASP-4; Casp11; CASP-11 |
| Background: | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015] |
| Category: | Primary Ab |
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