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查看说明书Recombinant Human Nicastrin / NCSTN Protein (His tag)
Cat#:TP07554应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Nicastrin Rabbit pAb |
| Cat No.: | DPA04653 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,FC,IP |
| Recommended Dilution: | WB: 1:1000 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Nicastrin |
| Calculated Molecular Weight: | 78 kDa |
| Observed Molecular Weight: | 110-120 kDa |
| GenBank Accession Number: | Q92542 |
| Gene ID (NCBI): | 23385 |
| Synonyms: | ATAG1874 |
| Background: | This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014] |
| Category: | Primary Ab |
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