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Presenilin 1 Recombinant Rabbit mAb

Cat No.: RMA01199
规格:
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  • Western blot analysis of Anti-Presenilin 1 antibody(RMA01199) Gel:10%SDS-PAGE Lysate: 20 μg Primary antibody: RMA01199(Presenilin 1 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: Presenilin 1 Recombinant Rabbit mAb
Cat No.: RMA01199
Clonality: Monoclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,IHC,ICC/IF,FC,IP
Recommended Dilution: WB,IHC,ICC/IF,FC,IP
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human Presenilin 1
Calculated Molecular Weight: 53 kDa
Observed Molecular Weight: 20 kDa
GenBank Accession Number: P49768
Gene ID (NCBI): 5663
Synonyms: AD3; FAD; PS1; PS-1; S182
Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Category: Primary Ab
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