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分子生物学
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查看说明书Presenilin 1 Rabbit pAb
Cat#:DPA04750应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | Phospho-Presenilin 1 (Ser310) Recombinant Rabbit mAb |
| Cat No.: | RMA02945 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF |
| Recommended Dilution: | WB: 1:2000 ICC/IF: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1 |
| Calculated Molecular Weight: | 53 kDa |
| Observed Molecular Weight: | 22 kDa |
| GenBank Accession Number: | P49768 |
| Gene ID (NCBI): | 5663 |
| Synonyms: | AD3; FAD; PS1; PS-1; S182 |
| Background: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] |
| Category: | Primary Ab |
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