产品中心

PMS2 Recombinant Rabbit mAb

Cat No.: RMA02875
规格:
查看说明书
  • Western blot analysis of Anti-PMS2 antibody(RMA02875) Gel: 6%SDS-PAGE Lysate: 20 μg Primary antibody: RMA02875(PMS2 antibody)at dilution 1:1000 Secondary antibody: Goat anti rabbit IgG (SPA10002)at 1:1000 dilution

Product Name: PMS2 Recombinant Rabbit mAb
Cat No.: RMA02875
Clonality: Monoclonal
Species Reactivity: Human
Tested Applications: WB, IHC, ICC/IF, FC, IP
Recommended Dilution: WB, IHC, ICC/IF, FC, IP
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human PMS2
Calculated Molecular Weight: 96 kDa
Observed Molecular Weight: 96 kDa
GenBank Accession Number: P54278
Gene ID (NCBI): 5395
Synonyms: MLH4; PMSL2; HNPCC4; PMS2CL
Background: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
Category: Primary Ab
武汉天正源生物科技有限公司 版权所有 | 鄂ICP备2023000437号-1