蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PMS2 Rabbit pAb
Cat#:DPA01352应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | PMS2 Rabbit pAb |
| Cat No.: | DPA01352 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:2000 IHC: 1:50 ICC/IF: 1:50 FC: 1:100 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human PMS2 |
| Calculated Molecular Weight: | 96 kDa |
| Observed Molecular Weight: | 96 kDa |
| GenBank Accession Number: | P54278 |
| Gene ID (NCBI): | 5395 |
| Synonyms: | MLH4; PMSL2; HNPCC4; PMS2CL |
| Background: | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016] |
| Category: | Primary Ab |
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