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Phospho-BRAF (Ser729) Rabbit pAb

Cat No.: DPA05424
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Product Name: Phospho-BRAF (Ser729) Rabbit pAb
Cat No.: DPA05424
Clonality: Polyclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,IHC
Recommended Dilution: WB: 1:1000
IHC: 1:50
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser729 of human BRAF
Calculated Molecular Weight: 84 kDa
Observed Molecular Weight: 84 kDa
GenBank Accession Number: P15056
Gene ID (NCBI): 673
Synonyms: NS7; B-raf; BRAF1; RAFB1; B-RAF1
Background: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Category: Primary Ab
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