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查看说明书Recombinant Fas Associating Death Domain Containing Protein (FADD)
Cat#:TP02080应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Phospho-FADD (Ser194) Rabbit pAb |
| Cat No.: | DPA05530 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser194 of human FADD |
| Calculated Molecular Weight: | 23 kDa |
| Observed Molecular Weight: | 28 kDa |
| GenBank Accession Number: | Q13158 |
| Gene ID (NCBI): | 8772 |
| Synonyms: | GIG3; MORT1 |
| Background: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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