蛋白
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检测试剂盒
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分子生物学
规格：
查看说明书AMPK alpha 2 Rabbit pAb
Cat#:DPA03910应用：WB,IP
| Product Name: | Phospho-AMPK alpha 2 (Ser491) Rabbit pAb |
| Cat No.: | DPA05549 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000-1:5000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser491 of human AMPK alpha 2 |
| Calculated Molecular Weight: | 62 kDa |
| Observed Molecular Weight: | 62 kDa |
| GenBank Accession Number: | P54646 |
| Gene ID (NCBI): | 5563 |
| Synonyms: | AMPK; AMPK2; PRKAA; AMPKa2 |
| Background: | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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