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查看说明书Recombinant Human PFK2 / PFKFB3 Protein (His & GST tag)
Cat#:TP08347应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Phospho-PFKFB3 (Ser461) Rabbit pAb |
| Cat No.: | DPA05579 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,ICC/IF |
| Recommended Dilution: | WB: 1:1000 ICC/IF: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser461 of human PFKFB3 |
| Calculated Molecular Weight: | 60 kDa |
| Observed Molecular Weight: | 60 kDa |
| GenBank Accession Number: | Q16875 |
| Gene ID (NCBI): | 5209 |
| Synonyms: | PFK2; IPFK2; iPFK-2 |
| Background: | The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] |
| Category: | Primary Ab |
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