蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书ULK1 Rabbit pAb
Cat#:DPA03224应用：WB
| Product Name: | ULK1 Rabbit pAb |
| Cat No.: | DPA03224 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:2000-1:10000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human ULK1 |
| Calculated Molecular Weight: | 113 kDa |
| Observed Molecular Weight: | 130 kDa |
| GenBank Accession Number: | O75385 |
| Gene ID (NCBI): | 8408 |
| Synonyms: | ATG1; ATG1A; UNC51; hATG1; Unc51.1 |
| Background: | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). |
| Category: | Primary Ab |
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